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Pharmacology

Харкевич Д.А.

NF0010081
978-5-9704-4307-1
2018
680
твердый

 

 

The 2nd edition of the textbook is revised and supplemented with new information. Modern considerations concerning the bases of pharmacotherapy of certain diseases are being discussed. Mechanisms of drug action are reviewed according to the latest achievements in fundamental pharmacology.

The textbook is designed for medical students.

I. INTRODUCTION
1. Subject and aims of pharmacology. Its position among other medical disciplines. Main stages of pharmacology development
2. Creation of new drugs
3. Main sections of pharmacology. Principles of classification of drugs


II. GENERAL PHARMACOLOGY
1. Drug administration routes. Absorption
2. Drug distribution in the body. Biological barriers. Storage
3. Biotransformation of drugs in the body
4. Routes of drug elimination from the body
5. Local and systemic effects of the drugs. Direct and reflex effects. Localization and mechanism of action. Drug "targets". Reversible and irreversible actions. Selective action
6. Dependence of pharmacotherapeutic action on drug properties and pattern of use
7. Importance of individual characteristics of the human body and its state for the manifestation of the drug effect
8. Main types of drug treatment
9. Principal and adverse effect. Allergic reactions. Idiosyncrasy. Toxic effects
10. General principles of the treatment of acute drug poisoning


III. SPECIAL PHARMACOLOGY
A. Drugs affecting afferent innervation


Chapter 1. Drugs decreasing sensitivity of afferent nerve endings or preventing their excitation
1.1. Local anesthetics
1.2. Astringents
1.3. Coating drugs
1.4. Adsorbents


Chapter 2. Drugs stimulating sensory nerve endings
2.1. Irritants
B. Drugs affecting efferent innervation


Chapter 3. Drugs affecting cholinergic synapses
3.1. Drugs affecting muscarinic and nicotinic cholinoceptors
3.2. Anticholinesterase drugs
3.3. Drugs affecting muscarinic cholinoceptors
3.4. Drugs affecting nicotinic cholinoceptors
А. Drugs blocking transmission in autonomic ganglia (ganglionic blockers, ganglion blocking agents)
B. Drugs blocking neuromuscular transmission (neuromuscular relaxants or peripheral muscle relaxants)


Chapter 4. Drugs affecting adrenergic synapses
4.1. Drugs stimulating adrenoceptors (adrenomimetics)
4.2. Drugs blocking adrenoceptors (adrenoceptor antagonists)
4.3. Drugs of presynaptic action
C. Drugs regulating the functions of the central nervous system (Chapters 5-12)


Chapter 5. General anesthetics
5.1. Drugs for inhalation anesthesia
5.2. Drugs for noninhalation anesthesia
5.3. Combined use of general anesthetics
5.4. Combined use of general anesthetics with drugs of different pharmacological groups


Chapter 6. Ethyl alcohol


Chapter 7. Hypnotics
7.1. Benzodiazepine receptor agonists
7.2. Melatonin receptor agonists
7.3. Hypnotics - non-selective CNS depressants


Chapter 8. Pain-relieving drugs (analgesics)
8.1. Opioid (narcotic) analgesics and their antagonists
8.2. Non-opioids of central action with analgesic activity
8.3. Analgesics with mixed mechanism of action (opioid + non-opioid)


Chapter 9. Antiepileptic drugs


Chapter 10. Antiparkinsonian drugs


Chapter 11. Psychotropic drugs
11.1. Antipsychotic drugs (neuroleptic drugs)
11.2. Antidepressants
11.3. Drugs used in manic states (antimanic drugs mood stabilizing drugs)
11.4. Anxiolytics (tranquilizers)
11.5. Sedatives
11.6. Psychostimulant drugs
11.7. Nootropic drugs (cognitive enhancers)


Chapter 12. Analeptics
D. Drugs regulating functions of major organs and systems


Chapter 13. Drugs affecting the respiratory system
13.1. Respiration stimulants
13.2. Antitussive drugs
13.3. Expectorants
13.4. Drugs used for the treatment of bronchospasm
13.5. Drugs used in acute respiratory failure


Chapter 14. Drugs affecting the cardiovascular system
14.1. Cardiotonic agents
14.2. Drugs used for the treatment of cardiac rhythm disturbances (antiarrhythmic drugs)
14.3. Drugs used for the treatment of ischemic heart disease
14.4. Drugs used for the treatment of cerebral blood circulation disorders
14.5. Antihypertensive drugs (hypotensive drugs)
14.6. Hypertensive drugs (drugs used for the treatment of arterial hypotension)
14.7. Venotropic (phlebotropic) drugs


Chapter 15. Drugs affecting the digestive system
15.1. Drugs that affect appetite
15.2. Drugs that affect salivary gland function
15.3. Drugs used for the treatment of gastric gland function disorder
15.4. Gastroprotectors
15.5. Drugs that affect gastric motility
15.6. Emetic and antiemetic drugs
15.7. Hepatoprotective drugs
15.8. Cholagogue drugs
15.9. Drugs that induce gallstone dissolution (cholelithiatic drugs)
15.10. Drugs used for the treatment of pancreatic failure
15.11. Drugs that affect intestinal motility


Chapter 16. Diuretics
16.1. Diuretics directly affecting the function of the renal tubular epithelium
16.2. Aldosterone antagonists
16.3. Osmotic diuretics


Chapter 17. Drugs affecting myometrium


Chapter 18. Drugs affecting hemopoiesis
18.1. Drugs affecting erythropoiesis
18.2. Drugs affecting leukopoiesis


Chapter 19. Drugs that affect platelet aggregation, blood coagulation and fibrinolysis
19.1. Drugs used for the prevention and treatment of thrombosis
19.2. Drugs that stop bleeding (hemostatics)
E. Drugs that control metabolic processes


Chapter 20. Hormonal drugs
20.1. Hypothalamic and pituitary hormones and their drugs
20.2. Hormones of the epiphysis and their drugs
20.3. Thyroid hormones and antithyroid drugs. Calcitonin
20.4. Parathyroid hormones and their drugs
20.5. Pancreatic hormones, their drugs and synthetic antidiabetic drugs
20.6. Adrenocorticosteroids, their drugs and antagonists
20.7. Sex hormones, their drugs and derivatives, synthetic substitutes and antagonists


Chapter 21. Vitamins
21.1. Water-soluble vitamins
21.2. Fat-soluble vitamins


Chapter 22. Antiatherosclerotic drugs (drugs used for the treatment of hyperlipoproteinemia)


Chapter 23. Drugs used for the treatment of obesity


Chapter 24. Drugs used for the treatment and prevention of osteoporosis


Chapter 25. Drugs used for the treatment of gout


Chapter 26. Anti-inflammatory drugs


Chapter 27. Drugs affecting the immune system
27.1. Antiallergic drugs. Immunosuppressants
27.2. Immunostimulators (immunomodulators)
F. Antimicrobial and antiparasitic drugs (Сhаpters 28-33)


Chapter 28. Antiseptics and disinfectants


Chapter 29. Antibacterial chemotherapeutic drugs
29.1. Antibiotics
29.2. Sulfonamides
29.3. Quinolone derivatives
29.4. Synthetic antibacterial agents of various chemical structures
29.5. Drugs for the treatment of syphilis
29.6. Antituberculosis drugs


Chapter 30. Antiviral drugs


Chapter 31. Antifungal agents


Chapter 32. Antiprotozoal drugs
32.1. Drugs used for the treatment and prophylaxis of malaria
32.2. Drugs used for the treatment of amebiasis
32.3. Drugs used for the treatment of giardiasis (lambliasis)
32.4. Drugs used for the treatment of trichomoniasis
32.5. Drugs used for the treatment of toxoplasmosis
32.6. Drugs used for the treatment of balantidiasis
32.7. Drugs used for the treatment of leishmaniasis
32.8. Drugs used for the treatment of trypanosomiasis


Chapter 33. Antihelminthic drugs
33.1. Drugs used for the treatment of intestinal helminthiasis
33.2. Drugs used for the treatment of extraintestinal helminthiasis


Chapter 34. Antineoplastic (antiblastomic) drugs
34.1. Alkylating agents and related compounds
34.2. Antimetabolites
34.3. Antibiotics
34.4. Plant derivatives
34.5. Hormones and hormone antagonists
34.6. Enzymes
34.7. Cytokines
34.8. Monoclonal antibodies
34.9. Protein kinase inhibitors
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